Cassiopeia build for Mid Patch 14.22

Detail build guide Cassiopeia build or position Mid with the highest win rate. Runes, items, and skill build guide in Patch 14.22.
Cassiopeia
Cassiopeia the Serpent's Embrace
Serpentine Grace Noxious Blast Q Miasma W Twin Fang E Petrifying Gaze R
VS.
Irelia
Matches 30
Win rate 26.67%
75%

Cassiopeia runes

44.00% WR (25 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Sorcery Sorcery
Summon Aery Arcane Comet Phase Rush
Nullifying Orb Manaflow Band Nimbus Cloak
Transcendence Celerity Absolute Focus
Scorch Waterwalking Gathering Storm
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE

Cassiopeia Summoner spells

Flash Teleport
52.00% WR (25 Matches)

Cassiopeia item build

Starter items

Health Potion Health Potion Tear of the Goddess
52.00% WR (25 Matches)

Boots

Core items

Tear of the Goddess Rod of Ages Seraph's Embrace Rylai's Crystal Scepter
72.73% WR (11 Matches)

Cassiopeia skill order

Skill Priority

Twin Fang E Noxious Blast Q Miasma W
52.17% WR (23 Matches)

Skill Path

Noxious Blast Q
Noxious Blast
2 8 10 12 13
Miasma W
Miasma
3 14 15
Twin Fang E
Twin Fang
1 4 5 7 9
Petrifying Gaze R
Petrifying Gaze
6 11
Serpentine Grace P
Serpentine Grace

Cassiopeia Toughest Matchups

Swain
Swain 26.67% 30 Matches
Lux
Lux 30.77% 52 Matches
Malzahar
Malzahar 31.91% 47 Matches
Veigar
Veigar 38.78% 49 Matches
Akali
Akali 45.16% 31 Matches
Katarina
Katarina 45.31% 64 Matches
Ahri
Ahri 46.53% 101 Matches

Cassiopeia Easy to fight general

Orianna
Orianna 69.44% 36 Matches
Lissandra
Lissandra 62.50% 32 Matches
Yone
Yone 58.70% 46 Matches
Yasuo
Yasuo 58.46% 65 Matches
Zed
Zed 57.50% 40 Matches
Syndra
Syndra 55.22% 67 Matches

Cassiopeia combos

Basic QAEEAEEAE
Medium R + F
Medium QEWEEERQEE
Expert QAEWEERFQEEE
Cassiopeia combos
Basic QAEEAEEAE
Medium R + F
Medium QEWEEERQEE
Expert QAEWEERFQEEE