Cassiopeia build for Mid Patch 14.22

Detail build guide Cassiopeia build or position Mid with the highest win rate. Runes, items, and skill build guide in Patch 14.22.
Cassiopeia
Cassiopeia the Serpent's Embrace
Serpentine Grace Noxious Blast Q Miasma W Twin Fang E Petrifying Gaze R
VS.
Irelia
Matches 39
Win rate 41.03%
70% 24%

Cassiopeia runes

62.50% WR (16 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Sorcery Sorcery
Summon Aery Arcane Comet Phase Rush
Nullifying Orb Manaflow Band Nimbus Cloak
Transcendence Celerity Absolute Focus
Scorch Waterwalking Gathering Storm
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE

Cassiopeia Summoner spells

Flash Teleport
62.50% WR (16 Matches)

Cassiopeia item build

Starter items

Health Potion Health Potion Tear of the Goddess
73.33% WR (15 Matches)

Boots

Core items

Tear of the Goddess Rod of Ages Seraph's Embrace Rylai's Crystal Scepter
66.67% WR (6 Matches)

Cassiopeia skill order

Skill Priority

Twin Fang E Noxious Blast Q Miasma W
81.82% WR (11 Matches)

Skill Path

Noxious Blast Q
Noxious Blast
2 8 10 12 13
Miasma W
Miasma
3 14 15
Twin Fang E
Twin Fang
1 4 5 7 9
Petrifying Gaze R
Petrifying Gaze
6 11
Serpentine Grace P
Serpentine Grace

Cassiopeia Toughest Matchups

Kassadin
Kassadin 40.54% 37 Matches
Ryze
Ryze 41.03% 39 Matches
Swain
Swain 41.03% 39 Matches
Galio
Galio 41.82% 55 Matches
Aurora
Aurora 43.33% 30 Matches
Lissandra
Lissandra 44.74% 38 Matches
Hwei
Hwei 45.61% 57 Matches

Cassiopeia Easy to fight general

Katarina
Katarina 61.96% 92 Matches
Viktor
Viktor 60.61% 33 Matches
Yasuo
Yasuo 59.76% 82 Matches
Orianna
Orianna 58.93% 56 Matches
Syndra
Syndra 58.76% 97 Matches
Malzahar
Malzahar 58.70% 46 Matches
Vex
Vex 55.26% 38 Matches

Cassiopeia combos

Basic QAEEAEEAE
Medium R + F
Medium QEWEEERQEE
Expert QAEWEERFQEEE
Cassiopeia combos
Basic QAEEAEEAE
Medium R + F
Medium QEWEEERQEE
Expert QAEWEERFQEEE