Vayne Runes for Top Path 14.21

Recommended Vayne runes for the Top path in patch 14.21, tailored for the current LoL meta.
Vayne
Vayne the Night Hunter
Night Hunter Tumble Q Silver Bolts W Condemn E Final Hour R
B Win rate 48.52% Pick rate 9.34% Ban rate 4.41% KDA 2.01
80% 17%

Keystones

Precision Lethal Tempo Resolve
61.90% 169 Matches
50.89% Win rate
Precision Press the Attack Resolve
15.02% 41 Matches
34.15% Win rate
Precision Fleet Footwork Sorcery
8.42% 23 Matches
52.17% Win rate
Precision Press the Attack Domination
3.66% 10 Matches
60.00% Win rate
Precision Lethal Tempo Domination
3.66% 10 Matches
70.00% Win rate

Vayne runes

50.35% WR (141 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
75.00% WR (8 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (4 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
36.36% WR (33 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (2 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
50.00% WR (22 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Sorcery Sorcery
Summon Aery Arcane Comet Phase Rush
Nullifying Orb Manaflow Band Nimbus Cloak
Transcendence Celerity Absolute Focus
Scorch Waterwalking Gathering Storm
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Sorcery Sorcery
Summon Aery Arcane Comet Phase Rush
Nullifying Orb Manaflow Band Nimbus Cloak
Transcendence Celerity Absolute Focus
Scorch Waterwalking Gathering Storm
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
50.00% WR (4 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
66.67% WR (3 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
50.00% WR (2 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (2 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE