Vayne Runes for Mid Path 14.21

Recommended Vayne runes for the Mid path in patch 14.21, tailored for the current LoL meta.
Vayne
Vayne the Night Hunter
Night Hunter Tumble Q Silver Bolts W Condemn E Final Hour R
S Win rate 52.84% Pick rate 9.58% Ban rate 7.11% KDA 2.18
87% 9%

Keystones

Precision Lethal Tempo Resolve
65.22% 15 Matches
26.67% Win rate
Precision Press the Attack Resolve
17.39% 4 Matches
25.00% Win rate
Precision Press the Attack Domination
8.70% 2 Matches
50.00% Win rate
Sorcery Summon Aery Domination
4.35% 1 Matches
100.00% Win rate
Precision Lethal Tempo Domination
4.35% 1 Matches
100.00% Win rate

Vayne runes

25.00% WR (12 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
33.33% WR (3 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Resolve Resolve
Grasp of the Undying Aftershock Guardian
Demolish Font of Life Shield Bash
Conditioning Second Wind Bone Plating
Overgrowth Revitalize Unflinching
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
0.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Sorcery Sorcery
Summon Aery Arcane Comet Phase Rush
Nullifying Orb Manaflow Band Nimbus Cloak
Transcendence Celerity Absolute Focus
Scorch Waterwalking Gathering Storm
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE
100.00% WR (1 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Domination Domination
Electrocute Dark Harvest Hail of Blades
Cheap Shot Taste of Blood Sudden Impact
Zombie Ward Ghost Poro Eyeball Collection
Treasure Hunter Relentless Hunter Ultimate Hunter
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE