Cassiopeia build for Mid Patch 14.22

Detail build guide Cassiopeia build or position Mid with the highest win rate. Runes, items, and skill build guide in Patch 14.22.
Cassiopeia
Cassiopeia the Serpent's Embrace
Serpentine Grace Noxious Blast Q Miasma W Twin Fang E Petrifying Gaze R
VS.
Diana
Matches 51
Win rate 43.14%
76%

Cassiopeia runes

59.09% WR (88 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Sorcery Sorcery
Summon Aery Arcane Comet Phase Rush
Nullifying Orb Manaflow Band Nimbus Cloak
Transcendence Celerity Absolute Focus
Scorch Waterwalking Gathering Storm
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE

Cassiopeia Summoner spells

Flash Teleport
59.57% WR (94 Matches)

Cassiopeia item build

Starter items

Health Potion Health Potion Tear of the Goddess
56.84% WR (95 Matches)

Boots

Core items

Tear of the Goddess Rod of Ages Seraph's Embrace Rylai's Crystal Scepter
65.63% WR (32 Matches)

Cassiopeia skill order

Skill Priority

Twin Fang E Noxious Blast Q Miasma W
68.49% WR (73 Matches)

Skill Path

Noxious Blast Q
Noxious Blast
2 8 10 12 13
Miasma W
Miasma
3 14 15
Twin Fang E
Twin Fang
1 4 5 7 9
Petrifying Gaze R
Petrifying Gaze
6 11
Serpentine Grace P
Serpentine Grace

Cassiopeia Toughest Matchups

Orianna
Orianna 34.62% 52 Matches
Malzahar
Malzahar 34.68% 124 Matches
Xerath
Xerath 36.76% 68 Matches
Smolder
Smolder 43.14% 51 Matches
Ryze
Ryze 45.16% 31 Matches
Fizz
Fizz 45.28% 106 Matches
Syndra
Syndra 46.05% 76 Matches

Cassiopeia Easy to fight general

Katarina
Katarina 60.29% 136 Matches
Ekko
Ekko 60.00% 35 Matches
Irelia
Irelia 59.26% 54 Matches
Ziggs
Ziggs 58.33% 36 Matches
Zed
Zed 57.83% 83 Matches
Diana
Diana 57.65% 85 Matches
Vex
Vex 57.04% 142 Matches

Cassiopeia combos

Basic QAEEAEEAE
Medium R + F
Medium QEWEEERQEE
Expert QAEWEERFQEEE
Cassiopeia combos
Basic QAEEAEEAE
Medium R + F
Medium QEWEEERQEE
Expert QAEWEERFQEEE