Cassiopeia build for Mid Patch 14.22

Detail build guide Cassiopeia build or position Mid with the highest win rate. Runes, items, and skill build guide in Patch 14.22.
Cassiopeia
Cassiopeia the Serpent's Embrace
Serpentine Grace Noxious Blast Q Miasma W Twin Fang E Petrifying Gaze R
VS.
Swain
Matches 49
Win rate 44.90%
78%

Cassiopeia runes

42.86% WR (21 Matches)
Precision Precision
Press the Attack Lethal Tempo Fleet Footwork Conqueror
Absorb Life Triumph Presence of Mind
Legend: Alacrity Legend: Haste Legend: Bloodline
Coup de Grace Cut Down Last Stand
Sorcery Sorcery
Summon Aery Arcane Comet Phase Rush
Nullifying Orb Manaflow Band Nimbus Cloak
Transcendence Celerity Absolute Focus
Scorch Waterwalking Gathering Storm
DEFENSE FLEX FLEX OFFENSE OFFENSE OFFENSE FLEX DEFENSE DEFENSE

Cassiopeia Summoner spells

Flash Teleport
41.94% WR (31 Matches)

Cassiopeia item build

Starter items

Health Potion Health Potion Tear of the Goddess
40.00% WR (20 Matches)

Boots

Core items

Tear of the Goddess Rod of Ages Seraph's Embrace Rylai's Crystal Scepter
33.33% WR (9 Matches)

Cassiopeia skill order

Skill Priority

Twin Fang E Noxious Blast Q Miasma W
47.37% WR (19 Matches)

Skill Path

Noxious Blast Q
Noxious Blast
2 8 10 12 13
Miasma W
Miasma
3 14 15
Twin Fang E
Twin Fang
1 4 5 7 9
Petrifying Gaze R
Petrifying Gaze
6 11
Serpentine Grace P
Serpentine Grace

Cassiopeia Toughest Matchups

Veigar
Veigar 43.75% 32 Matches
Yasuo
Yasuo 44.90% 49 Matches
Syndra
Syndra 45.00% 40 Matches
Ahri
Ahri 45.07% 71 Matches
Irelia
Irelia 45.16% 31 Matches
Katarina
Katarina 50.00% 44 Matches
Hwei
Hwei 50.00% 30 Matches

Cassiopeia Easy to fight general

Yone
Yone 64.29% 42 Matches
Orianna
Orianna 60.00% 30 Matches
Sylas
Sylas 58.44% 77 Matches

Cassiopeia combos

Basic QAEEAEEAE
Medium R + F
Medium QEWEEERQEE
Expert QAEWEERFQEEE
Cassiopeia combos
Basic QAEEAEEAE
Medium R + F
Medium QEWEEERQEE
Expert QAEWEERFQEEE